PMC lesions correlate with LUTS in MS

Periventricular lesions correlate with cortical thinning in multiple sclerosis.

OBJECTIVE It has been suggested recently that cortical pathology in multiple sclerosis (MS) may, at least partly, be caused by factors in cerebrospinal fluid (CSF). We thus hypothesized that MS-related tissue changes in compartments close to the CSF, such as periventricular lesions, might correlate with cortical pathology. METHODS We investigated a cohort of 160 patients, comprising 91 with a...

Parallelizing Monte Carlo with PMC

Cortical Lesions in MS: Assessment at 7T

Introduction Multiple sclerosis is generally thought of as a white matter (WM) disease [1], yet there is limited correlation between white matter lesion (WML) load and neurological deficits found clinically [2]. Cortical damage was identified early [3,4] and has recently been correlated with the neurological episodes of MS patients [5]. Pathologically, cortical lesions (CLs) are classified into...

Limited TCF7L2 Expression in MS Lesions

Multiple sclerosis is the most frequent demyelinating disease in the human CNS characterized by inflammation, demyelination, relative axonal loss and gliosis. Remyelination occurs, but is frequently absent or restricted to a small remyelinated rim at the lesion border. Impaired differentiation of oligodendroglial precursor cells is one factor contributing to limited remyelination, especially in...

Europe PMC in 2017

Europe PMC (https://europepmc.org) is a comprehensive resource of biomedical research publications that offers advanced tools for search, retrieval, and interaction with the scientific literature. This article outlines new developments since 2014. In addition to delivering the core database and services, Europe PMC focuses on three areas of development: individual user services, data integratio...